"Ua hoʻopili ʻia ka Baking Soda (Sodium Bicarbonate) ʻaʻohe ʻawaʻawa a me ka ʻino ʻole i loko o kahi nano 'capsule' palekana (liposome), a ua kau ʻia ka tetracycline me ka ikaika e hoʻopaʻa ai i ka iwi ma luna o ka ʻili e hoʻopili i ka ʻili o ka iwi. Ke luku nā osteoclasts i nā ʻiʻo iwi ma ka huna ʻana i ka waikawa, hiki iā lākou ke hoʻokuʻu koke i ka Sodium Bicarbonate, e kāohi ana i ka hana o nā osteoclasts a hoʻokō i ka pahuhopu o ka pale ʻana i ka osteoporosis ma ke kumu." Ua paʻi koke ʻia kahi hui i alakaʻi ʻia e Polofesa Shunwu Fan o ka 'Oihana Orthopedics, Run Run Shaw Hospital, Zhejiang University, a me Polofesa Ruikang Tang o ka 'Oihana Chemistry, Zhejiang University, i kā lākou mau ʻike ma ka Journal of the American Chemical Society.
Wahi a ka hoʻolauna, ua like nā osteoclasts me nā ʻuku i loko o ka lāʻau, i ka manawa hoʻokahi e hana ana, ʻoiai ke kumu kiʻekiʻe, akā no ka palaho lōʻihi a me ka hāʻule ʻana. Manaʻo nā haʻawina o kēia manawa ʻo ke kumu nui o ka osteoporosis ka hoʻoulu ʻana o nā osteoclasts, a ʻo ka hoʻokuʻu ʻana o ka waikawa e nā osteoclasts ua manaʻo ʻia ʻo ia ke kumu mua o ka luku ʻia ʻana o ka iwi e nā osteoclasts a me ke kumu kūpono no ko lākou hōʻino ʻana i ka ʻiʻo iwi.
ʻO nā lāʻau lapaʻau nui i ka mālama lapaʻau ʻana o ka osteoporosis e hoʻokō i ke kumu o ka anti-bone resorption a me ka hoʻolaha ʻana i ka anabolism iwi ma o ka nānā ʻana i ka hoʻoponopono ʻana o ka osteoclast a i ʻole osteoblast biology, akā ʻaʻole lākou e pepehi i ke kaʻina mua koʻikoʻi o ke kaiapuni waikawa waho o ka hoʻokumu ʻana o osteoclast mai ke kumu. No laila, hiki i nā lāʻau lapaʻau e kū nei ke hoʻolohi i ka nalowale o ka iwi i ka poʻe ʻelemakule i kekahi ʻano, akā ʻaʻole hiki ke hoʻohuli piha i ka luku ʻia ʻana o ka iwi i hana ʻia, a ʻo ka hoʻokele koho ʻana o nā lāʻau lapaʻau ʻaʻole iwi hiki ke alakaʻi i nā hopena ʻino a me nā hopena ʻino ʻē aʻe o nā kino.
Eia kekahi, ʻoiai ʻo nā osteoclasts ke kumu o ka osteoporosis, ua hōʻike nā haʻawina he nui he kuleana ko lākou i ka hoʻolaha ʻana i ka hoʻokumu ʻana o ka iwi a me ka angiogenesis ma ke ʻano he "precursor cells" ma mua o ka hoʻokuʻu ʻana i ka waikawa. No laila, he mea nui loa ka pale pololei ʻana i nā osteoclasts.
Ua hoʻomaka ka hui a Fan Shunwu a me ka hui a Tang Ruikang i ka hoʻopili ʻana o nā liposome Sodium Bicarbonate i ka ʻili o ka iwi, e hana ana i kahi papa pale alkaline, e hoʻopau ana i ka waikawa i hūnā ʻia e nā osteoclasts, e kāohi ana i ka hoʻoulu ʻana o nā osteoclasts, a me ke ʻano hou ʻana i ke kaulike o ka microenvironment iwi e hoʻokō ai i ka hopena o ka mālama ʻana i ka osteoporosis.
Ua ʻōlelo ʻo Lin Xianfeng, he kauka orthopedic ma ka Halemai ʻo Run Run Shaw o ke Kulanui ʻo Zhejiang, ua ʻike ʻia ka noiʻi ua hoʻoulu nā mea liposome alkaline a me ke kaiapuni acidic kūloko o nā osteoclasts i ka nui o ka apoptosis o nā osteoclasts, a ua hoʻokuʻu hou aku i ka nui o nā vesicles extracellular. "Ua like ia me kahi hoʻonohonoho o nā dominoes, i hoʻokuke ʻia i hoʻokahi papa i ka manawa a hoʻonui ʻia i hoʻokahi ʻanuʻu i ka manawa e pale piha i ka luku ʻia ʻana o ka iwi i hoʻokumu ʻia e ka hoʻoikaika ʻana o nā osteoclasts."
Ka manawa hoʻouna: Ian-27-2021