"Hoʻopili ʻia ka Baking Soda non-ʻawahia a hōʻino ʻole (Sodium Bicarbonate) i kahi nano 'capsule' (liposome), a ua kau ʻia ka tetracycline me ka ikaika paʻa iwi i luna e hoʻolaha i ka ʻili iwi. Ke hoʻopau nā osteoclasts i ka iwi nāʻiʻo ma o ka hūnā ʻana i ka waikawa, hiki iā lākou ke hoʻokuʻu koke iā Sodium Bicarbonate, e kāohi ana i ka hana o nā osteoclasts a me ka hoʻokō ʻana i ka pahuhopu o ka pale ʻana i ka osteoporosis ma mua. " ʻO kahi hui i alakaʻi ʻia e Professor Shunwu Fan o ka Oihana o Orthopedics, Run Run Shaw Hospital, Zhejiang University, a me Professor Ruikang Tang o ka Department of Chemistry, Zhejiang University, i hoʻopuka hou i kā lākou ʻike i ka Ka Puke Pai o ka American Chemical Society.
Wahi a ka hoʻolauna, ua like nā osteoclast me nā termite i loko o ka lāʻau, i ka manawa e hana ai, ʻo ia hoʻi ka lāʻau kiʻekiʻe, akā no ka palaho a me ka hāʻule hoʻi. Manaʻo nā noiʻi o kēia manawa ke kumu mua o ka osteoporosis ka hoʻāʻo kino ʻole ʻana o nā osteoclasts, a ʻo ka huna ʻia ʻana o ka waikawa e nā osteoclasts ke kumu nui o ka luku ʻia ʻana o ka iwi e nā osteoclasts a me nā mea e pono ai no ka hoʻohaʻahaʻa ʻia o nā iwi iwi.
ʻO nā lāʻau lapaʻau nui i ka mālama kino ʻana o ka osteoporosis e hoʻokō i ke kumu o ka resorption anti-iwi a me ka paipai ʻana i ka anabolism iwi ma o ka nānā ʻana i ke ʻano o ka osteoclast a i ʻole osteoblast biology, akā ʻaʻole lākou e pepehi i ke kī mua o ke kaika waikaho kūwaho o ka hoʻokumu osteoclast mai ka kumuwaiwai. No laila, hiki i nā lāʻau i kēia manawa ke hoʻolohi i ka nalo ʻana o ka iwi i kahi ʻelemākule i kekahi nui, akā ʻaʻole hiki pinepine ke hoʻohuli loa i ka luku ʻia ʻana o ka iwi i kū aʻe, a me ka hoʻokele pono ʻana o nā lāʻau nonbone i hiki ke alakaʻi ʻia i ka pahuhopu pahuhopu a me nā hopena ʻona ʻino o nā ʻokana.
Eia hou, ʻoiai ʻo ka osteoclasts ke kumu o ka osteoporosis, ua hōʻike ʻia nā noiʻi he nui lākou i ka paipai ʻana i ka hoʻokumu iwi a me ka angiogenesis ma ke ʻano he "precursor cells" ma mua o ka hūnā ʻana o ka waikawa. No laila, he mea nui e kāohi pololei i nā osteoclasts.
ʻO ka hui a Fan Shunwu a me kā ka hui ʻo Tang Ruikang i hoʻokumu i ka pahuhopu o Sodium Bicarbonate liposomes i ka ʻili iwi, e hana ana i kahi pale pale alkaline, hoʻoneʻe ʻana i ka waikawa huna ʻia e nā osteoclasts, ke kāohi nei i ka hoʻāpono o nā osteoclasts, a me ka hoʻololi hou ʻana i ke kaulike o ka microen environment o ka iwi e hoʻokō i ka hopena o ka mālama ʻana i ka osteoporosis .
Ua ʻōlelo ʻo Lin Xianfeng, kahi kaukō lapaʻau orthopedic ma ka Halemai ʻo Run Run Shaw o ke Kulanui ʻo Zhejiang, ua hōʻike ʻia ua hoʻopaʻa ʻia nā mea liposome alkaline a me nā wahi acidic kūloko o nā osteoclasts i kahi nui o nā apoptosis o osteoclasts, a hoʻokuʻu hou i kahi nui o nā vesic extracellular extracellular. "He ʻano like ia o nā domino, i hoʻokau ʻia i hoʻokahi papa i ka manawa a hoʻonui ʻia i kēlā me kēia manawa i ke kūʻē ʻana i ka luku ʻia ʻana o ka iwi i hoʻokumu ʻia e ka hoʻoikaika ʻana i nā osteoclasts."
Ka manawa Post: Ian-27-2021